New autoantibodies in early rheumatoid arthritis
Identifieur interne : 001F34 ( Main/Exploration ); précédent : 001F33; suivant : 001F35New autoantibodies in early rheumatoid arthritis
Auteurs : Caroline Charpin [France] ; Fanny Arnoux [France] ; Marielle Martin [France] ; Eric Toussirot [France] ; Nathalie Lambert [France] ; Nathalie Balandraud [France] ; Daniel Wendling [France] ; Elisabeth Diot [France] ; Jean Roudier [France] ; Isabelle Auger [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Autoanticorps (immunologie), Autoanticorps (sang), Autoantigènes (immunologie), Cartographie épitopique, Femelle, Humains, Marqueurs biologiques (sang), Mâle, Polyarthrite rhumatoïde (diagnostic), Polyarthrite rhumatoïde (immunologie), Polyarthrite rhumatoïde (sang), Test ELISA.
- MESH :
- diagnostic : Polyarthrite rhumatoïde.
- immunologie : Autoanticorps, Autoantigènes, Polyarthrite rhumatoïde.
- sang : Autoanticorps, Marqueurs biologiques, Polyarthrite rhumatoïde.
- Adulte, Adulte d'âge moyen, Analyse par réseau de protéines, Cartographie épitopique, Femelle, Humains, Mâle, Test ELISA.
English descriptors
- KwdEn :
- Adult, Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (diagnosis), Arthritis, Rheumatoid (immunology), Autoantibodies (blood), Autoantibodies (immunology), Autoantigens (immunology), Biomarkers (blood), Enzyme-Linked Immunosorbent Assay, Epitope Mapping, Female, Humans, Male, Middle Aged, Protein Array Analysis.
- MESH :
- chemical , blood : Autoantibodies, Biomarkers.
- blood : Arthritis, Rheumatoid.
- diagnosis : Arthritis, Rheumatoid.
- immunology : Arthritis, Rheumatoid, Autoantibodies, Autoantigens.
- Adult, Enzyme-Linked Immunosorbent Assay, Epitope Mapping, Female, Humans, Male, Middle Aged, Protein Array Analysis.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.
We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.
WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.
We identified new autoantibodies associated with RA with disease duration less than one year. These autoantibodies could be used as diagnosis markers in RA patients.
Url:
DOI: 10.1186/ar4255
PubMed: 23886014
PubMed Central: 3978570
Affiliations:
- France
- Bourgogne-Franche-Comté, Centre-Val de Loire, Franche-Comté, Provence-Alpes-Côte d'Azur, Région Centre
- Besançon, Marseille, Tours
- Université d'Aix-Marseille
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Le document en format XML
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Charpin</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Arnoux, Fanny" sort="Arnoux, Fanny" uniqKey="Arnoux F" first="Fanny" last="Arnoux">Fanny Arnoux</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Martin, Marielle" sort="Martin, Marielle" uniqKey="Martin M" first="Marielle" last="Martin">Marielle Martin</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Toussirot, Eric" sort="Toussirot, Eric" uniqKey="Toussirot E" first="Eric" last="Toussirot">Eric Toussirot</name><affiliation wicri:level="3"><nlm:aff id="I3">Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Nathalie" sort="Lambert, Nathalie" uniqKey="Lambert N" first="Nathalie" last="Lambert">Nathalie Lambert</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name><affiliation wicri:level="3"><nlm:aff id="I3">Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Rhumatologie, CHU Jean Minjoz, 2 Boulevard Fleming, 25030 Besançon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name><affiliation wicri:level="3"><nlm:aff id="I4">Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne, CHU Bretonneau, 2 Boulevard Tonnellé, 37000 Tours</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name><affiliation wicri:level="4"><nlm:aff id="I1">INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMRs 1097, Aix Marseille Université, 163 Avenue de Luminy, 13288 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology, IML, APHM, 270 Boulevard de Sainte Marguerite, 13009 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when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Arthritis, Rheumatoid (blood)</term><term>Arthritis, Rheumatoid (diagnosis)</term><term>Arthritis, Rheumatoid (immunology)</term><term>Autoantibodies (blood)</term><term>Autoantibodies (immunology)</term><term>Autoantigens (immunology)</term><term>Biomarkers (blood)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Epitope Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Protein Array Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse par réseau de protéines</term><term>Autoanticorps (immunologie)</term><term>Autoanticorps (sang)</term><term>Autoantigènes (immunologie)</term><term>Cartographie épitopique</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Polyarthrite rhumatoïde (diagnostic)</term><term>Polyarthrite rhumatoïde (immunologie)</term><term>Polyarthrite rhumatoïde (sang)</term><term>Test ELISA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Autoanticorps</term><term>Autoantigènes</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Autoantibodies</term><term>Autoantigens</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Autoanticorps</term><term>Marqueurs biologiques</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Epitope Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Protein Array Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse par réseau de protéines</term><term>Cartographie épitopique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Rheumatoid arthritis (RA) is a chronic inflammatory joint disease causing articular cartilage and bone destruction. Since irreversible joint destruction can be prevented by intervention at the early stages of disease, early diagnosis of RA is important. In this study, we identified new autoantibodies in the sera of patients with early (less than one year) RA.</p></sec><sec><title>Methods</title><p>We screened the sera of 20 RA patients with disease duration less than one year, 19 RA patients with disease duration more than five years and 23 controls on 8,268 human protein arrays. We confirmed the validity of protein array detection by ELISA assays. We then performed epitope mapping with overlapping 15-mers to analyze RA sera reactivity.</p></sec><sec><title>Results</title><p>WIBG (within BGCN homolog (Drosophila)), GABARAPL2 (GABA(A) receptor associated protein like 2) and ZNF706 (zinc finger protein 706) proteins are preferentially recognized by autoantibodies from early RA patients. Of interest, autoantibodies to WIBG are very specific for early RA. Indeed, 33% of early RA patients' sera recognize WIBG versus 5% of RA patients with disease duration more than 5 years and 2% of controls. We identified three linear peptides on WIBG GABARAPL2 and ZNF706 that are preferentially recognized by sera of early RA patients.</p></sec><sec><title>Conclusions</title><p>We identified new autoantibodies associated with RA with disease duration less than one year. 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d'Aix-Marseille</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name></region><name sortKey="Arnoux, Fanny" sort="Arnoux, Fanny" uniqKey="Arnoux F" first="Fanny" last="Arnoux">Fanny Arnoux</name><name sortKey="Auger, Isabelle" sort="Auger, Isabelle" uniqKey="Auger I" first="Isabelle" last="Auger">Isabelle Auger</name><name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name><name sortKey="Balandraud, Nathalie" sort="Balandraud, Nathalie" uniqKey="Balandraud N" first="Nathalie" last="Balandraud">Nathalie Balandraud</name><name sortKey="Charpin, Caroline" sort="Charpin, Caroline" uniqKey="Charpin C" first="Caroline" last="Charpin">Caroline Charpin</name><name sortKey="Diot, Elisabeth" sort="Diot, Elisabeth" uniqKey="Diot E" first="Elisabeth" last="Diot">Elisabeth Diot</name><name sortKey="Lambert, Nathalie" sort="Lambert, Nathalie" uniqKey="Lambert N" first="Nathalie" last="Lambert">Nathalie Lambert</name><name sortKey="Martin, Marielle" sort="Martin, Marielle" uniqKey="Martin M" first="Marielle" last="Martin">Marielle Martin</name><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name><name sortKey="Roudier, Jean" sort="Roudier, Jean" uniqKey="Roudier J" first="Jean" last="Roudier">Jean Roudier</name><name sortKey="Toussirot, Eric" sort="Toussirot, Eric" uniqKey="Toussirot E" first="Eric" last="Toussirot">Eric Toussirot</name><name sortKey="Wendling, Daniel" sort="Wendling, Daniel" uniqKey="Wendling D" first="Daniel" last="Wendling">Daniel Wendling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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